On a wet and sloppy track at Churchill Downs, Orb charged through the mud to a victory, giving Hall of Fame trainer Shug McGaughey his first win in the Derby.
Golden Soul finished second with Revolutionary coming in third.
Orb, the 5-1 favorite, ran the 1 1/4 miles in 2:02.89. He paid $12.80, $7.40 and $5.40. Golden Soul returned $38.60 and $19.40 while Revolutionary paid $5.40 to show.
McGaughey said the victory meant everything to him. "I'm thrilled to death for (the owners), thrilled to death for the people who put so much time into this horse, and, of course, I'm thrilled to death for me," he said.